The principal aim of ME Research UK is to commission and fund high-quality scientific (biomedical) investigation into the causes, consequences and treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (also known as ME/CFS). This is a debilitating illness which affects between 120,000 and 240,000 people in the UK, but is neither well understood nor, in many cases, properly recognised. We also have a mission to Energise ME Research, which involves raising awareness of the need for biomedical research into ME/CFS globally, and providing high quality information on all aspects of the illness for a wide range of audiences – from summarising and appraising scientific literature on ME/CFS to informing the policy agenda.